Amyloidosis is a rare disease in itself but it is also a possible complication of some rare autoinflammatory conditions, including TRAPS, FMF, SJIA and HIDS. If your child is affected by any of these conditions, it’s a good idea to learn a bit more about amyloidosis, so you can spot the possible signs and symptoms, and understand how it can be treated.
Amyloidosis occurs when an abnormal protein called amyloid builds up in an organ. Amyloid can be deposited in any organ but in rare autoinflammatory conditions it usually gathers in the kidneys. When the amyloid proteins build up, they stop the kidneys from working properly and can eventually lead to kidney failure if left untreated.
Symptoms of amyloidosis in the kidney may include:
If you notice your child experiencing some of these symptoms, be sure to talk to the doctor.
Amyloidosis occurs when abnormal cells in the bone marrow produce abnormal proteins called amyloid. These proteins can enter the blood and travel to the kidneys, or other organs, where they clump together into strings-like structures called fibrils. The body can’t clear these fibrils easily, meaning they build up in the organ and slowly stop it from working properly.
Amyloidosis is a rare complication of TRAPS, FMF, SJIA and HIDS. Not much is yet known about the connection between rare autoinflammatory diseases and amyloidosis but there is some evidence that genetics play a role. Research has also shown that a shorter time between disease onset and beginning treatment, is associated with a lower risk of developing amyloidosis in certain rare autoinflammatory conditions.
Further research is needed in order to understand more about the connection between rare autoinflammatory diseases and amyloidosis.
Blood tests and urine tests can identify high levels of abnormal proteins in the blood or urine and this can help in providing a diagnosis. A final diagnosis requires a biopsy of the kidney, or other affected organ, which means taking a very small sample of organ tissue to analyse under a microscope.
There are a number of treatment methods available for managing the symptoms of
amyloidosis, such as pain medication and treatment for fluid retention.
Recent advances in diagnosing amyloidosis helps to pinpoint a person’s precise type. This makes it possible to directly treat the cause of someone’s amyloidosis, for example through methods that reduce the production of amyloid thereby reducing the levels of amyloid.
Speak to a doctor or another healthcare professional if you would like to learn more about amyloidosis or if you recognize the symptoms of amyloidosis in your child.
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